1 Beta Release 0.1.3 (XX April, 2009)
2 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
4 Notable changes in SAMtools:
6 * SAMtools is more consistent with the specification: a) '*' in the
7 QUAL field is allowed; b) the field separator is TAB only and SPACE
8 is treated as a character in a field; c) empty header is allowed.
10 * Implemented GLFv3 support in pileup.
12 * Fixed a severe bug in fixmate: strand information is wrongly
15 * Fixed a bug in alignment retrieval: alignments bridging n*16384bp are
16 not correctly retrieved sometimes.
18 * Move indel_filter.pl to samtools.pl and improved the filtering by
19 checking the actual number of alignments containing indels. The indel
20 pileup line is also changed a little to make this filtration easier.
22 * Fixed a minor bug in indexing: the bin number of an unmapped read is
25 * Added `flagstat' command to show statistics on the FLAG field.
27 * Improved indel caller by setting the maximum window size in local
30 Changes in other utilities:
32 * Fixed a bug in maq2sam: a tag name is obsolete.
34 * Improvement to wgsim: a) added support for SOLiD read simulation; b)
35 show the number of substitutions/indels/errors in read name; c)
36 considerable code clean up.
38 * Various converters: improved functionality in general.
40 (0.1.3: XX April 2009, rXXX)
44 Beta Release 0.1.2 (28 January, 2008)
45 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
47 Notable changes in SAMtools:
49 * Implemented a Bayesian indel caller. The new caller generate scores
50 and genotype and is potentially more accurate than Maq's indel
51 caller. The pileup format is also changed accordingly.
53 * Implemented rmdup command: remove potential PCR duplicates. Note that
54 this command ONLY works for FR orientation and requires ISIZE is
57 * Added fixmate command: fill in mate coordinates, ISIZE and mate
58 related flags from a name-sorted alignment.
60 * Fixed a bug in indexing: reads bridging 16x kbp were not retrieved.
62 * Allow to select reads shown in the pileup output with a mask.
64 * Generate GLFv2 from pileup.
66 * Added two more flags for flagging PCR/optical duplicates and for QC
69 * Fixed a bug in sort command: name sorting for large alignment did not
72 * Allow to completely disable RAZF (using Makefile.lite) as some people
73 have problem to compile it.
75 * Fixed a bug in import command when there are reads without
78 * Fixed a bug in tview: clipping broke the alignment viewer.
80 * Fixed a compiling error when _NO_CURSES is applied.
82 * Fixed a bug in merge command.
84 Changes in other utilities:
86 * Added wgsim, a paired-end reads simulator. Wgsim was adapted from
87 maq's reads simulator. Colin Hercus further improved it to allow
90 * Added wgsim_eval.pl, a script that evaluates the accuracy of
91 alignment on reads generated by wgsim.
93 * Added soap2sam.pl, a SOAP2->SAM converter. This converter does not
94 work properly when multiple hits are output.
96 * Added bowtie2sam.pl, a Bowtie->SAM converter. Only the top hit will
97 be retained when multiple hits are present.
99 * Fixed a bug in export2sam.pl for QC reads.
101 * Support RG tag at MAQ->SAM converter.
103 * Added novo2sam.pl, a NovoAlign->SAM converter. Multiple hits and
104 indel are not properly handled, though.
106 * Added zoom2sam.pl, a ZOOM->SAM converter. It only works with the
107 default Illumina output.
109 (0.1.2: 28 January 2008; r116)
113 Beta Release 0.1.1 (22 December, 2008)
114 ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~
116 The is the first public release of samtools. For more information,
117 please check the manual page `samtools.1' and the samtools website
118 http://samtools.sourceforge.net