-This file is a subset of the 'input_file'. It only contains the genes/transcripts called as differentially expressed (DE). When more than 2 conditions exist, DE is defined as not all conditions are equally expressed.
+This file is a subset of the 'input_file'. It only contains the genes/transcripts called as differentially expressed (DE). When more than 2 conditions exist, DE is defined as not all conditions are equally expressed. Because statistical significance does not necessarily mean biological significance, users should also refer to the fold changes to decide which genes/transcripts are biologically significant. When more than two conditions exist, this file will not contain fold change information and users need to calculate it from 'input_file.condmeans' by themselves.