+++ /dev/null
-/*
- * mothurfisher.cpp
- * Mothur
- *
- * Created by westcott on 7/8/11.
- * Copyright 2011 Schloss Lab. All rights reserved.
- *
- */
-
-//translated to c++ using source code http://www.langsrud.com/stat/fisher.htm as a reference
-
-#include "mothurfisher.h"
-/***********************************************************/
-double MothurFisher::fexact(double n11_, double n12_, double n21_, double n22_) {
- try {
- sleft = 0.0; sright = 0.0; sless = 0.0; slarg = 0.0;
-
- if(n11_<0) n11_ *= -1;
- if(n12_<0) n12_ *= -1;
- if(n21_<0) n21_ *= -1;
- if(n22_<0) n22_ *= -1;
-
- double n1_ = n11_+n12_;
- double n_1 = n11_+n21_;
- double n = n11_ +n12_ +n21_ +n22_;
- exact(n11_,n1_,n_1,n);
- double twotail = sleft+sright;
-
- if(twotail>1) twotail=1;
- double result = twotail;
- return result;
-
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "fexact");
- exit(1);
- }
-}
-/***********************************************************/
-double MothurFisher::lngamm(double z) {
- // Reference: "Lanczos, C. 'A precision approximation
- // of the gamma function', J. SIAM Numer. Anal., B, 1, 86-96, 1964."
- // Translation of Alan Miller's FORTRAN-implementation
- // See http://lib.stat.cmu.edu/apstat/245
- try {
- double x = 0;
- x += 0.1659470187408462e-06/(z+7);
- x += 0.9934937113930748e-05/(z+6);
- x -= 0.1385710331296526 /(z+5);
- x += 12.50734324009056 /(z+4);
- x -= 176.6150291498386 /(z+3);
- x += 771.3234287757674 /(z+2);
- x -= 1259.139216722289 /(z+1);
- x += 676.5203681218835 /(z);
- x += 0.9999999999995183;
-
- return(log(x)-5.58106146679532777-z+(z-0.5)*log(z+6.5));
-
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "lngamm");
- exit(1);
- }
-}
-
-/***********************************************************/
-double MothurFisher::lnfact(double n){
- try {
- if(n <= 1) return(0);
- return(lngamm(n+1));
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "lnfact");
- exit(1);
- }
-}
-/***********************************************************/
-double MothurFisher::lnbico(double n, double k){
- try {
- return(lnfact(n)-lnfact(k)-lnfact(n-k));
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "lnbico");
- exit(1);
- }
-}
-/***********************************************************/
-double MothurFisher::hyper_323(double n11, double n1_, double n_1, double n){
- try {
- return(exp(lnbico(n1_,n11)+lnbico(n-n1_,n_1-n11)-lnbico(n,n_1)));
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "hyper_323");
- exit(1);
- }
-}
-/***********************************************************/
-double MothurFisher::myhyper(double n11){
- try {
- double hyper0Result = hyper0(n11,0,0,0);
- return hyper0Result;
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "myhyper");
- exit(1);
- }
-}
-/***********************************************************/
-double MothurFisher::hyper0(double n11i, double n1_i, double n_1i, double ni) {
- try {
- if (!((n1_i != 0)&&(n_1i != 0)&&(ni != 0))) {
- if(!(((int)n11i % 10) == 0)){
- if(n11i==sn11+1)
- {
- sprob *= ((sn1_-sn11)/(n11i))*((sn_1-sn11)/(n11i+sn-sn1_-sn_1));
- sn11 = n11i;
- return sprob;
- }
- if(n11i==sn11-1)
- {
- sprob *= ((sn11)/(sn1_-n11i))*((sn11+sn-sn1_-sn_1)/(sn_1-n11i));
- sn11 = n11i;
- return sprob;
- }
- }
- sn11 = n11i;
- }else{
- sn11 = n11i;
- sn1_=n1_i;
- sn_1=n_1i;
- sn=ni;
- }
-
- sprob = hyper_323(sn11,sn1_,sn_1,sn);
- return sprob;
-
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "hyper0");
- exit(1);
- }
-}
-/***********************************************************/
-double MothurFisher::exact(double n11, double n1_, double n_1, double n){
- try {
- double p,i,j,prob;
- double max=n1_;
- if(n_1<max) max=n_1;
- double min = n1_+n_1-n;
- if(min<0) min=0;
- if(min==max)
- {
- sless = 1;
- sright= 1;
- sleft = 1;
- slarg = 1;
- return 1;
- }
- prob=hyper0(n11,n1_,n_1,n);
- sleft=0;
- p=myhyper(min);
- for(i=min+1; p<0.99999999*prob; i++)
- {
- sleft += p;
- p=myhyper(i);
- }
- i--;
- if(p<1.00000001*prob) sleft += p;
- else i--;
- sright=0;
- p=myhyper(max);
- for(j=max-1; p<0.99999999*prob; j--)
- {
- sright += p;
- p=myhyper(j);
- }
- j++;
- if(p<1.00000001*prob) sright += p;
- else j++;
- if(abs(i-n11)<abs(j-n11))
- {
- sless = sleft;
- slarg = 1 - sleft + prob;
- }
- else
- {
- sless = 1 - sright + prob;
- slarg = sright;
- }
- return prob;
-
- }catch(exception& e) {
- m->errorOut(e, "MothurFisher", "exact");
- exit(1);
- }
-}
-/***********************************************************/
-
-
-