fractid.cpp

   1 #include "myutils.h"\r
   2 #include "alpha.h"\r
   3 \r
   4 //unsigned g_MaxL = 0;\r
   5 \r
   6 static bool *g_IsChar = g_IsAminoChar;\r
   7 \r
   8 // Term gaps allowed in query (A) only\r
   9 static double GetFractIdGivenPathDerep(const byte *A, const byte *B, const char *Path,\r
  10   char *ptrDesc)\r
  11         {\r
  12         if (*Path == 'D')\r
  13                 {\r
  14                 if (ptrDesc != 0)\r
  15                         sprintf(ptrDesc, "(term gap in Query)");\r
  16                 return 0;\r
  17                 }\r
  18 \r
  19         const char *LastM = 0;\r
  20         for (const char *p = Path; *p; ++p)\r
  21                 if (*p == 'M')\r
  22                         LastM = p;\r
  23 \r
  24         unsigned PosA = 0;\r
  25         unsigned PosB = 0;\r
  26         unsigned Ids = 0;\r
  27         unsigned Diffs = 0;\r
  28         unsigned Cols = 0;\r
  29         for (const char *p = Path; *p && p != LastM; ++p)\r
  30                 {\r
  31                 ++Cols;\r
  32                 char c = *p;\r
  33                 if (c == 'M')\r
  34                         {\r
  35                         byte a = toupper(A[PosA]);\r
  36                         byte b = toupper(B[PosB]);\r
  37                         if (g_IsChar[a] && g_IsChar[b])\r
  38                                 {\r
  39                                 if (a == b)\r
  40                                         ++Ids;\r
  41                                 else\r
  42                                         ++Diffs;\r
  43                                 }\r
  44                         else\r
  45                                 --Cols;\r
  46                         }\r
  47                 if (c == 'D' || c == 'I')\r
  48                         ++Diffs;\r
  49                 if (c == 'M' || c == 'D')\r
  50                         ++PosA;\r
  51                 if (c == 'M' || c == 'I')\r
  52                         ++PosB;\r
  53                 }\r
  54 \r
  55         double FractId = (Cols == 0 ? 0.0 : 1.0 - double(Diffs)/double(Cols));\r
  56         if (ptrDesc != 0)\r
  57                 sprintf(ptrDesc, "(ids=%u/cols=%u)", Ids, Cols);\r
  58         return FractId;\r
  59         }\r
  60 \r
  61 static double GetFractIdGivenPathAllDiffs(const byte *A, const byte *B, const char *Path,\r
  62   char *ptrDesc)\r
  63         {\r
  64         unsigned PosA = 0;\r
  65         unsigned PosB = 0;\r
  66         unsigned Ids = 0;\r
  67         unsigned Diffs = 0;\r
  68         unsigned Cols = 0;\r
  69         for (const char *p = Path; *p; ++p)\r
  70                 {\r
  71                 ++Cols;\r
  72                 char c = *p;\r
  73                 if (c == 'M')\r
  74                         {\r
  75                         byte a = toupper(A[PosA]);\r
  76                         byte b = toupper(B[PosB]);\r
  77                         if (g_IsChar[a] && g_IsChar[b])\r
  78                                 {\r
  79                                 if (a == b)\r
  80                                         ++Ids;\r
  81                                 else\r
  82                                         ++Diffs;\r
  83                                 }\r
  84                         else\r
  85                                 --Cols;\r
  86                         }\r
  87                 if (c == 'D' || c == 'I')\r
  88                         ++Diffs;\r
  89                 if (c == 'M' || c == 'D')\r
  90                         ++PosA;\r
  91                 if (c == 'M' || c == 'I')\r
  92                         ++PosB;\r
  93                 }\r
  94 \r
  95         double FractId = (Cols == 0 ? 0.0 : 1.0 - double(Diffs)/double(Cols));\r
  96         if (ptrDesc != 0)\r
  97                 sprintf(ptrDesc, "(ids=%u/cols=%u)", Ids, Cols);\r
  98         return FractId;\r
  99         }\r
 100 \r
 101 static double GetFractIdGivenPathInternalDiffs(const byte *A, const byte *B,\r
 102   const char *Path, char *ptrDesc)\r
 103         {\r
 104         unsigned i = 0;\r
 105         unsigned FirstM = UINT_MAX;\r
 106         unsigned LastM = UINT_MAX;\r
 107         for (const char *p = Path; *p; ++p)\r
 108                 {\r
 109                 if (*p == 'M')\r
 110                         {\r
 111                         if (FirstM == UINT_MAX)\r
 112                                 FirstM = i;\r
 113                         LastM = i;\r
 114                         }\r
 115                 ++i;\r
 116                 }\r
 117         if (FirstM == UINT_MAX)\r
 118                 {\r
 119                 if (ptrDesc != 0)\r
 120                         strcpy(ptrDesc, "(no matches)");\r
 121                 return 0.0;\r
 122                 }\r
 123 \r
 124         unsigned PosA = 0;\r
 125         unsigned PosB = 0;\r
 126         unsigned Ids = 0;\r
 127         unsigned Diffs = 0;\r
 128         unsigned Cols = 0;\r
 129         for (unsigned i = 0; i < FirstM; ++i)\r
 130                 {\r
 131                 char c = Path[i];\r
 132                 if (c == 'M' || c == 'D')\r
 133                         ++PosA;\r
 134                 if (c == 'M' || c == 'I')\r
 135                         ++PosB;\r
 136                 }\r
 137 \r
 138         for (unsigned i = FirstM; i <= LastM; ++i)\r
 139                 {\r
 140                 ++Cols;\r
 141                 char c = Path[i];\r
 142                 if (c == 'M')\r
 143                         {\r
 144                         byte a = toupper(A[PosA]);\r
 145                         byte b = toupper(B[PosB]);\r
 146                         if (g_IsChar[a] && g_IsChar[b])\r
 147                                 {\r
 148                                 if (a == b)\r
 149                                         ++Ids;\r
 150                                 else\r
 151                                         ++Diffs;\r
 152                                 }\r
 153                         else\r
 154                                 --Cols;\r
 155                         }\r
 156                 if (c == 'D' || c == 'I')\r
 157                         ++Diffs;\r
 158                 if (c == 'M' || c == 'D')\r
 159                         ++PosA;\r
 160                 if (c == 'M' || c == 'I')\r
 161                         ++PosB;\r
 162                 }\r
 163 \r
 164         double FractId = (Cols == 0 ? 0.0 : 1.0 - double(Diffs)/double(Cols));\r
 165         if (ptrDesc != 0)\r
 166                 sprintf(ptrDesc, "(ids=%u/cols=%u)", Ids, Cols);\r
 167         return FractId;\r
 168         }\r
 169 \r
 170 static double GetFractIdGivenPathMBL(const byte *A, const byte *B, const char *Path,\r
 171   char *ptrDesc)\r
 172         {\r
 173         unsigned PosA = 0;\r
 174         unsigned PosB = 0;\r
 175         unsigned Mismatches = 0;\r
 176         unsigned Gaps = 0;\r
 177         for (const char *p = Path; *p; ++p)\r
 178                 {\r
 179                 char c = *p;\r
 180                 if (c == 'M' && toupper(A[PosA]) != toupper(B[PosB]))\r
 181                         ++Mismatches;\r
 182                 if (c == 'D' || c == 'I' && (p == Path || p[-1] == 'M'))\r
 183                         ++Gaps;\r
 184                 if (c == 'M' || c == 'D')\r
 185                         ++PosA;\r
 186                 if (c == 'M' || c == 'I')\r
 187                         ++PosB;\r
 188                 }\r
 189         unsigned Diffs = Gaps + Mismatches;\r
 190         double FractDiffs = (PosB == 0 ? 0.0 : double(Diffs)/double(PosB));\r
 191         if (ptrDesc != 0)\r
 192                 sprintf(ptrDesc, "Gap opens %u, Id=1 - [(diffs=%u)/(target_length=%u)]",\r
 193                   Gaps, Diffs, PosB);\r
 194         double FractId = 1.0 - FractDiffs;\r
 195         if (FractId < 0.0)\r
 196                 return 0.0;\r
 197         return FractId;\r
 198         }\r
 199 \r
 200 static double GetFractIdGivenPathBLAST(const byte *A, const byte *B, const char *Path,\r
 201   char *ptrDesc)\r
 202         {\r
 203         unsigned PosA = 0;\r
 204         unsigned PosB = 0;\r
 205         unsigned Ids = 0;\r
 206         unsigned Wilds = 0;\r
 207         unsigned Cols = 0;\r
 208         for (const char *p = Path; *p; ++p)\r
 209                 {\r
 210                 ++Cols;\r
 211                 char c = *p;\r
 212                 if (c == 'M')\r
 213                         {\r
 214                         byte a = toupper(A[PosA]);\r
 215                         byte b = toupper(B[PosB]);\r
 216                         if (g_IsChar[a] && g_IsChar[b])\r
 217                                 {\r
 218                                 if (a == b)\r
 219                                         ++Ids;\r
 220                                 }\r
 221                         else\r
 222                                 ++Wilds;\r
 223                         }\r
 224                 if (c == 'M' || c == 'D')\r
 225                         ++PosA;\r
 226                 if (c == 'M' || c == 'I')\r
 227                         ++PosB;\r
 228                 }\r
 229         asserta(Cols >= Wilds);\r
 230         Cols -= Wilds;\r
 231         double FractId = Cols == 0 ? 0.0f : float(Ids)/float(Cols);\r
 232         if (ptrDesc != 0)\r
 233                 sprintf(ptrDesc, "(ids=%u/cols=%u)", Ids, Cols);\r
 234         return FractId;\r
 235         }\r
 236 \r
 237 static double GetFractIdGivenPathDefault(const byte *A, const byte *B, const char *Path,\r
 238   char *ptrDesc)\r
 239         {\r
 240         unsigned PosA = 0;\r
 241         unsigned PosB = 0;\r
 242         unsigned Ids = 0;\r
 243         unsigned Wilds = 0;\r
 244         for (const char *p = Path; *p; ++p)\r
 245                 {\r
 246                 char c = *p;\r
 247                 if (c == 'M')\r
 248                         {\r
 249                         byte a = toupper(A[PosA]);\r
 250                         byte b = toupper(B[PosB]);\r
 251                         if (g_IsChar[a] && g_IsChar[b])\r
 252                                 {\r
 253                                 if (a == b)\r
 254                                         ++Ids;\r
 255                                 }\r
 256                         else\r
 257                                 ++Wilds;\r
 258                         }\r
 259                 if (c == 'M' || c == 'D')\r
 260                         ++PosA;\r
 261                 if (c == 'M' || c == 'I')\r
 262                         ++PosB;\r
 263                 }\r
 264         unsigned MinLen = min(PosA, PosB) - Wilds;\r
 265         double FractId = (MinLen == 0 ? 0.0 : double(Ids)/double(MinLen));\r
 266         if (ptrDesc != 0)\r
 267                 sprintf(ptrDesc, "(ids=%u/shorter_length=%u)", Ids, MinLen);\r
 268         return FractId;\r
 269         }\r
 270 \r
 271 double GetFractIdGivenPath(const byte *A, const byte *B, const char *Path,\r
 272   bool Nucleo, char *ptrDesc, unsigned IdDef)\r
 273         {\r
 274         if (Nucleo)\r
 275                 g_IsChar = g_IsACGTU;\r
 276         else\r
 277                 g_IsChar = g_IsAminoChar;\r
 278 \r
 279         if (Path == 0)\r
 280                 {\r
 281                 if (ptrDesc != 0)\r
 282                         strcpy(ptrDesc, "(NULL path)");\r
 283                 return 0.0;\r
 284                 }\r
 285 \r
 286         unsigned ColCount = (unsigned) strlen(Path);\r
 287         if (ColCount == 0)\r
 288                 return 0.0;\r
 289 \r
 290         if (opt_leftjust)\r
 291                 {\r
 292                 if (Path[0] != 'M' || Path[ColCount-1] == 'D')\r
 293                         {\r
 294                         if (ptrDesc != 0)\r
 295                                 strcpy(ptrDesc, "(leftjust)");\r
 296                         return 0.0;\r
 297                         }\r
 298                 }\r
 299 \r
 300         if (opt_rightjust)\r
 301                 {\r
 302                 if (Path[0] == 'D' || Path[ColCount-1] != 'M')\r
 303                         {\r
 304                         if (ptrDesc != 0)\r
 305                                 strcpy(ptrDesc, "(rightjust)");\r
 306                         return 0.0;\r
 307                         }\r
 308                 }\r
 309 \r
 310         double FractId = 0.0;\r
 311         //if (opt_idprefix > 0)\r
 312         //      {\r
 313         //      for (unsigned i = 0; i < opt_idprefix; ++i)\r
 314         //              {\r
 315         //              char c = Path[i];\r
 316         //              if (c != 'M' || toupper(A[i]) != toupper(B[i]))\r
 317         //                      {\r
 318         //                      if (ptrDesc != 0)\r
 319         //                              sprintf(ptrDesc, "Prefix ids %u < idprefix(%u)",\r
 320         //                                i, opt_idprefix);\r
 321         //                      return 0.0;\r
 322         //                      }\r
 323         //              }\r
 324         //      }\r
 325 \r
 326         //if (opt_idsuffix > 0)\r
 327         //      {\r
 328         //      unsigned Cols = strlen(Path);\r
 329         //      for (unsigned i = 0; i < opt_idsuffix && i > Cols; ++i)\r
 330         //              {\r
 331         //              unsigned k = Cols - 1 - i;\r
 332         //              char c = Path[k];\r
 333         //              if (c != 'M' || toupper(A[k]) != toupper(B[k]))\r
 334         //                      {\r
 335         //                      if (ptrDesc != 0)\r
 336         //                              sprintf(ptrDesc, "Suffix ids %u < idsuffix(%u)",\r
 337         //                                i, opt_idsuffix);\r
 338         //                      return 0.0;\r
 339         //                      }\r
 340         //              }\r
 341         //      }\r
 342 \r
 343         if (opt_maxqgap > 0 || opt_maxtgap > 0)\r
 344                 {\r
 345                 unsigned L = 0;\r
 346                 const char *LastM = 0;\r
 347                 for (const char *p = Path; *p; ++p)\r
 348                         if (*p == 'M')\r
 349                                 LastM = p;\r
 350 \r
 351 //              g_MaxL = 0;\r
 352                 for (const char *p = Path; *p && p != LastM; ++p)\r
 353                         {\r
 354                         char c = *p;\r
 355                         switch (c)\r
 356                                 {\r
 357                         case 'M':\r
 358                                 if (L > 0)\r
 359                                         {\r
 360                                         if (p[-1] == 'D')\r
 361                                                 {\r
 362                                                 if (L > opt_maxtgap)\r
 363                                                         {\r
 364                                                         if (ptrDesc != 0)\r
 365                                                                 sprintf(ptrDesc, "(maxtgap)");\r
 366                                                         return 0.0;\r
 367                                                         }\r
 368                                                 }\r
 369                                         else if (p[-1] == 'I')\r
 370                                                 {\r
 371                                                 if (L > opt_maxqgap)\r
 372                                                         {\r
 373                                                         if (ptrDesc != 0)\r
 374                                                                 sprintf(ptrDesc, "(maxqgap)");\r
 375                                                         return 0.0;\r
 376                                                         }\r
 377                                                 }\r
 378                                         else\r
 379                                                 asserta(false);\r
 380                                         }\r
 381                                 L = 0;\r
 382                                 break;\r
 383 \r
 384                         case 'D':\r
 385                         case 'I':\r
 386                                 ++L;\r
 387                                 //if (L > g_MaxL)\r
 388                                 //      g_MaxL = L;\r
 389                                 break;\r
 390 \r
 391                         default:\r
 392                                 asserta(false);\r
 393                                 }\r
 394                         }\r
 395                 }\r
 396 \r
 397         switch (IdDef)\r
 398                 {\r
 399         case 0:\r
 400                 FractId = GetFractIdGivenPathDefault(A, B, Path, ptrDesc);\r
 401                 break;\r
 402 \r
 403         case 1:\r
 404                 FractId = GetFractIdGivenPathAllDiffs(A, B, Path, ptrDesc);\r
 405                 break;\r
 406 \r
 407         case 2:\r
 408                 FractId = GetFractIdGivenPathInternalDiffs(A, B, Path, ptrDesc);\r
 409                 break;\r
 410 \r
 411         case 3:\r
 412                 FractId = GetFractIdGivenPathMBL(A, B, Path, ptrDesc);\r
 413                 break;\r
 414 \r
 415         case 4:\r
 416                 FractId = GetFractIdGivenPathBLAST(A, B, Path, ptrDesc);\r
 417                 break;\r
 418 \r
 419         case 5:\r
 420                 FractId = GetFractIdGivenPathDerep(A, B, Path, ptrDesc);\r
 421                 break;\r
 422 \r
 423         default:\r
 424                 Die("--iddef %u invalid", opt_iddef);\r
 425                 }\r
 426 \r
 427         return FractId;\r
 428         }\r
 429 \r
 430 double GetFractIdGivenPath(const byte *A, const byte *B, const char *Path,\r
 431   bool Nucleo, char *ptrDesc)\r
 432         {\r
 433         return GetFractIdGivenPath(A, B, Path, Nucleo, ptrDesc, opt_iddef);\r
 434         }\r
 435 \r
 436 double GetFractIdGivenPath(const byte *A, const byte *B, const char *Path, bool Nucleo)\r
 437         {\r
 438         return GetFractIdGivenPath(A, B, Path, Nucleo, (char *) 0);\r
 439         }\r
 440 \r
 441 double GetFractIdGivenPath(const byte *A, const byte *B, const string &Path)\r
 442         {\r
 443         return GetFractIdGivenPath(A, B, Path.c_str(), true);\r
 444         }\r
 445 \r
 446 double GetFractIdGivenPath(const byte *A, const byte *B, const char *Path)\r
 447         {\r
 448         return GetFractIdGivenPath(A, B, Path, true);\r
 449         }\r