System Requirements =================== SAMtools depends on the zlib library . The latest version 1.2.3 is preferred and with the latest version you can compile razip and use it to compress a FASTA file. SAMtools' faidx is able to index a razip-compressed FASTA file to save diskspace. Older zlib also works with SAMtools, but razip cannot be compiled. The text-based viewer (tview) requires the GNU ncurses library , which comes with Mac OS X and most of the modern Linux/Unix distributions. If you do not have this library installed, you can still compile the rest of SAMtools by manually modifying two lines in Makefile as is described in the Makefile. Compilation =========== Type `make' to compile samtools. If you have zlib >= 1.2.2.1, you can compile razip with `make razip'. Installation ============ Simply copy `samtools' and other executables/scripts in `misc' to a location you want (e.g. a directory in your $PATH). No further configurations are required.