From 68bd5e29b8f58b46ea9ca406a92f023ac7035eb4 Mon Sep 17 00:00:00 2001 From: Don Armstrong Date: Mon, 20 Mar 2017 19:24:05 -0700 Subject: [PATCH 1/1] add start of raphael changes --- kinetic_formalism_competition.Rnw | 17 +++++++++-------- 1 file changed, 9 insertions(+), 8 deletions(-) diff --git a/kinetic_formalism_competition.Rnw b/kinetic_formalism_competition.Rnw index fbc0307..2a47cf4 100644 --- a/kinetic_formalism_competition.Rnw +++ b/kinetic_formalism_competition.Rnw @@ -120,7 +120,7 @@ to.kcal <- function(k,temp=300) { % double check this with the bits in the paper For a system with monomers $(_\mathrm{monomer})$ and a vesicle -$(_\mathrm{vesicle})$, the change in composition of the $i$th component of +$(_\mathrm{vesicle})$, the change in concentration of the $i$th component of a lipid vesicle per change in time ($d \left[C_{i_\mathrm{vesicle}}\right]/dt$) can be described by a modification of the basic mass action law: @@ -541,7 +541,7 @@ unsaturated and saturated lipids forming heterogeneous domains. Void formation is increased when the unsaturation of lipids in the vesicle is widely distributed; in other words, the insertion of lipids into the membrane is greater when the standard deviation of the -unsaturation is larger % +unsaturation is larger. % %%% \RZ{May need to site (at least for us) works showing %%% mismatch-dependent ``defects''}. % Assuming that an increase in width of the distribution linearly @@ -808,7 +808,7 @@ reasonable base for $x$ is 2, leading to: \end{equation} The most common $\mathrm{stdev} l_\mathrm{vesicle}$ is around $3.4$, which leads to -a range of $\Delta \Delta G^\ddagger$ of +a $\Delta \Delta G^\ddagger$ of $\Sexpr{format(digits=3,to.kcal(2^(3.4)))} \frac{\mathrm{kcal}}{\mathrm{mol}}$. @@ -896,7 +896,7 @@ Just as the forward rate constant adjustment $k_{\mathrm{f}i\mathrm{adj}}$ does, the backwards rate constant adjustment $k_{\mathrm{b}i\mathrm{adj}}$ takes into account unsaturation ($un_\mathrm{b}$), charge ($ch_\mathrm{b}$), curvature ($cu_\mathrm{b}$), length ($l_\mathrm{b}$), and complex formation ($CF1_\mathrm{b}$), each of -which are modified depending on the specific component and the vesicle +which is modified depending on the specific component and the vesicle from which the component is exiting: @@ -992,10 +992,11 @@ popViewport(2) \end{figure} \subsubsection{Charge Backwards} -As in the case of monomers entering a vesicle, monomers leaving a -vesicle leave faster if their charge has the same sign as the average -charge vesicle. An equation of the form $ch_\mathrm{b} = a^{\left - ch_m}$ is then appropriate, and using a base of $a=20$ yields: +As in the case of monomers entering a vesicle, opposites attract. +Monomers leaving a vesicle leave faster if their charge has the same +sign as the average charge vesicle. An equation of the form +$ch_\mathrm{b} = a^{\left ch_m}$ is then appropriate, and +using a base of $a=20$ yields: \begin{equation} ch_\mathrm{b} = 20^{\left<{ch}_v\right> {ch}_m} -- 2.39.2