From: Don Armstrong Date: Fri, 30 Dec 2011 19:42:10 +0000 (-0800) Subject: add ncf2 pnas paper post X-Git-Url: https://git.donarmstrong.com/?p=don.git;a=commitdiff_plain;h=a29dcee88e281a8a85d2be686bc64565367173f6 add ncf2 pnas paper post --- diff --git a/posts/ncf2_pnas_paper.mdwn b/posts/ncf2_pnas_paper.mdwn new file mode 100644 index 0000000..a07912e --- /dev/null +++ b/posts/ncf2_pnas_paper.mdwn @@ -0,0 +1,13 @@ +[[!meta title="Causative SLE allele in NCF2 paper published"]] + +This year has been fairly good for our lab; a few years ago we found +an association of +[rs17849502](http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=rs17849502) +with SLE. Finally, after significant work by our collaborators, we +managed to demonstrate a functional significance of this SNP with +possible importance for SLE. Changing H389 to Q reduces the function +of the NADPH oxidase complex by 50% in Vav dependent Fcγ response. + +You can read the paper +["Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase."](http://www.pnas.org/cgi/pmidlookup?view=long&pmid=22203994) +(pmid: [22203994](http://www.ncbi.nlm.nih.gov/pubmed/22203994))