[[!meta title="Causative SLE allele in NCF2 paper published"]] This year has been fairly good for our lab; a few years ago we found an association of [rs17849502](http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=rs17849502) with SLE. Finally, after significant work by our collaborators, we managed to demonstrate a functional significance of this SNP with possible importance for SLE. Changing H389 to Q reduces the function of the NADPH oxidase complex by 50% in Vav dependent Fcγ response. You can read the paper ["Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase."](http://www.pnas.org/cgi/pmidlookup?view=long&pmid=22203994) (pmid: [22203994](http://www.ncbi.nlm.nih.gov/pubmed/22203994)) [[!tag biology genetics snp]]