X-Git-Url: https://git.donarmstrong.com/?a=blobdiff_plain;f=bcftools%2Fbcfutils.c;h=0eab4c1f322b398750fdda9da4caec6eea8e7579;hb=9f118264ea012adc21a46d7c03eaad4f9ce7d4d4;hp=91cc2c23ccb33c66c944fe013df1e92a84867858;hpb=d382711a770f67a72b9af3bfd98a88fbced34f64;p=samtools.git

diff --git a/bcftools/bcfutils.c b/bcftools/bcfutils.c
index 91cc2c2..0eab4c1 100644
--- a/bcftools/bcfutils.c
+++ b/bcftools/bcfutils.c
@@ -5,6 +5,12 @@
 #include "khash.h"
 KHASH_MAP_INIT_STR(str2id, int)
 
+#ifdef _WIN32
+#define srand48(x) srand(x)
+#define drand48() ((double)rand() / RAND_MAX)
+#endif
+
+// FIXME: valgrind report a memory leak in this function. Probably it does not get deallocated...
 void *bcf_build_refhash(bcf_hdr_t *h)
 {
 	khash_t(str2id) *hash;
@@ -168,6 +174,27 @@ int bcf_fix_pl(bcf1_t *b)
 	return 0;
 }
 
+int bcf_smpl_covered(const bcf1_t *b)
+{
+	int i, j, n = 0;
+	uint32_t tmp;
+	bcf_ginfo_t *gi;
+	// pinpoint PL
+	tmp = bcf_str2int("PL", 2);
+	for (i = 0; i < b->n_gi; ++i)
+		if (b->gi[i].fmt == tmp) break;
+	if (i == b->n_gi) return 0;
+	// count how many samples having PL!=[0..0]
+	gi = b->gi + i;
+	for (i = 0; i < b->n_smpl; ++i) {
+		uint8_t *PLi = ((uint8_t*)gi->data) + i * gi->len;
+		for (j = 0; j < gi->len; ++j)
+			if (PLi[j]) break;
+		if (j < gi->len) ++n;
+	}
+	return n;
+}
+
 static void *locate_field(const bcf1_t *b, const char *fmt, int l)
 {
 	int i;
@@ -287,3 +314,77 @@ int bcf_subsam(int n_smpl, int *list, bcf1_t *b)
 	b->n_smpl = n_smpl;
 	return 0;
 }
+
+static int8_t nt4_table[128] = {
+	4, 4, 4, 4,  4, 4, 4, 4,  4, 4, 4, 4,  4, 4, 4, 4, 
+	4, 4, 4, 4,  4, 4, 4, 4,  4, 4, 4, 4,  4, 4, 4, 4, 
+	4, 4, 4, 4,  4, 4, 4, 4,  4, 4, 4, 4,  4, 4 /*'-'*/, 4, 4,
+	4, 4, 4, 4,  4, 4, 4, 4,  4, 4, 4, 4,  4, 4, 4, 4, 
+	4, 0, 4, 1,  4, 4, 4, 2,  4, 4, 4, 4,  4, 4, 4, 4, 
+	4, 4, 4, 4,  3, 4, 4, 4, -1, 4, 4, 4,  4, 4, 4, 4, 
+	4, 0, 4, 1,  4, 4, 4, 2,  4, 4, 4, 4,  4, 4, 4, 4, 
+	4, 4, 4, 4,  3, 4, 4, 4, -1, 4, 4, 4,  4, 4, 4, 4
+};
+
+int bcf_gl10(const bcf1_t *b, uint8_t *gl)
+{
+	int a[4], k, l, map[4], k1, j, i;
+	const bcf_ginfo_t *PL;
+	char *s;
+	if (b->ref[1] != 0 || b->n_alleles > 4) return -1; // ref is not a single base or >4 alleles
+	for (i = 0; i < b->n_gi; ++i)
+		if (b->gi[i].fmt == bcf_str2int("PL", 2)) break;
+	if (i == b->n_gi) return -1; // no PL
+	PL = b->gi + i;
+	a[0] = nt4_table[(int)b->ref[0]];
+	if (a[0] > 3 || a[0] < 0) return -1; // ref is not A/C/G/T
+	a[1] = a[2] = a[3] = -2; // -1 has a special meaning
+	if (b->alt[0] == 0) return -1; // no alternate allele
+	map[0] = map[1] = map[2] = map[3] = -2;
+	map[a[0]] = 0;
+	for (k = 0, s = b->alt, k1 = -1; k < 3 && *s; ++k, s += 2) {
+		if (s[1] != ',' && s[1] != 0) return -1; // ALT is not single base
+		a[k+1] = nt4_table[(int)*s];
+		if (a[k+1] >= 0) map[a[k+1]] = k+1;
+		else k1 = k + 1;
+		if (s[1] == 0) break; // the end of the ALT string
+	}
+	for (k = 0; k < 4; ++k)
+		if (map[k] < 0) map[k] = k1;
+	for (i = 0; i < b->n_smpl; ++i) {
+		const uint8_t *p = PL->data + i * PL->len; // the PL for the i-th individual
+		uint8_t *g = gl + 10 * i;
+		for (k = j = 0; k < 4; ++k) {
+			for (l = k; l < 4; ++l) {
+				int t, x = map[k], y = map[l];
+				if (x > y) t = x, x = y, y = t; // make sure x is the smaller
+				g[j++] = p[y * (y+1) / 2 + x];
+			}
+		}
+	}
+	return 0;
+}
+
+int bcf_gl10_indel(const bcf1_t *b, uint8_t *gl)
+{
+	int k, l, j, i;
+	const bcf_ginfo_t *PL;
+	if (b->alt[0] == 0) return -1; // no alternate allele
+	for (i = 0; i < b->n_gi; ++i)
+		if (b->gi[i].fmt == bcf_str2int("PL", 2)) break;
+	if (i == b->n_gi) return -1; // no PL
+	PL = b->gi + i;
+	for (i = 0; i < b->n_smpl; ++i) {
+		const uint8_t *p = PL->data + i * PL->len; // the PL for the i-th individual
+		uint8_t *g = gl + 10 * i;
+		for (k = j = 0; k < 4; ++k) {
+			for (l = k; l < 4; ++l) {
+				int t, x = k, y = l;
+				if (x > y) t = x, x = y, y = t; // make sure x is the smaller
+				x = y * (y+1) / 2 + x;
+				g[j++] = x < PL->len? p[x] : 255;
+			}
+		}
+	}
+	return 0;
+}