X-Git-Url: https://git.donarmstrong.com/?a=blobdiff_plain;f=bam2bcf.h;h=b2b1825cd59a17a1973b040f722f1efb13ef24f0;hb=28391e5898804ce6b805016d8c676fdf61442eb3;hp=3d9a8043a0b65bea590643b3ac34d9c07b214b89;hpb=7eaf231bcd3c44fad56f8d7200e44a37ae453c88;p=samtools.git diff --git a/bam2bcf.h b/bam2bcf.h index 3d9a804..b2b1825 100644 --- a/bam2bcf.h +++ b/bam2bcf.h @@ -2,33 +2,63 @@ #define BAM2BCF_H #include -#include "bcf.h" +#include "errmod.h" +#include "bcftools/bcf.h" -struct __bcf_callaux_t; -typedef struct __bcf_callaux_t bcf_callaux_t; +#define B2B_INDEL_NULL 10000 + +#define B2B_FMT_DP 0x1 +#define B2B_FMT_SP 0x2 +#define B2B_FMT_DV 0x4 + +typedef struct __bcf_callaux_t { + int capQ, min_baseQ; + int openQ, extQ, tandemQ; // for indels + int min_support, max_support; // for collecting indel candidates + double min_frac, max_frac; // for collecting indel candidates + int per_sample_flt; // indel filtering strategy + int *ref_pos, *alt_pos, npos; // for ReadPosBias + // for internal uses + int max_bases; + int indel_types[4]; + int maxins, indelreg; + int read_len; + char *inscns; + uint16_t *bases; + errmod_t *e; + void *rghash; +} bcf_callaux_t; typedef struct { - int depth; - uint64_t sum_Q2; - float p[16], esum[4]; + int depth, n_supp, ori_depth, qsum[4]; + unsigned int anno[16]; + float p[25]; } bcf_callret1_t; typedef struct { - int a[4]; // alleles: ref, alt, alt2, alt3 - int n, n_alleles, shift, ori_ref; - int depth, rmsQ; + int a[5]; // alleles: ref, alt, alt2, alt3 + float qsum[4]; + int n, n_alleles, shift, ori_ref, unseen; + int n_supp; // number of supporting non-reference reads + unsigned int anno[16], depth, ori_depth; uint8_t *PL; + float vdb; // variant distance bias + float read_pos_bias; + struct { float avg, var; int dp; } read_pos; } bcf_call_t; #ifdef __cplusplus extern "C" { #endif - bcf_callaux_t *bcf_call_init(double theta); + bcf_callaux_t *bcf_call_init(double theta, int min_baseQ); void bcf_call_destroy(bcf_callaux_t *bca); - int bcf_call_glfgen(int _n, const bam_pileup1_t *pl, int ref_base /*4-bit*/, bcf_callaux_t *bca, bcf_callret1_t *r); - int bcf_call_combine(int n, const bcf_callret1_t *calls, int ref_base /*4-bit*/, bcf_call_t *call); - int bcf_call2bcf(int tid, int pos, bcf_call_t *bc, bcf1_t *b); + int bcf_call_glfgen(int _n, const bam_pileup1_t *pl, int ref_base, bcf_callaux_t *bca, bcf_callret1_t *r); + int bcf_call_combine(int n, const bcf_callret1_t *calls, bcf_callaux_t *bca, int ref_base /*4-bit*/, bcf_call_t *call); + int bcf_call2bcf(int tid, int pos, bcf_call_t *bc, bcf1_t *b, bcf_callret1_t *bcr, int fmt_flag, + const bcf_callaux_t *bca, const char *ref); + int bcf_call_gap_prep(int n, int *n_plp, bam_pileup1_t **plp, int pos, bcf_callaux_t *bca, const char *ref, + const void *rghash); #ifdef __cplusplus }