X-Git-Url: https://git.donarmstrong.com/?a=blobdiff_plain;f=bam2bcf.h;h=a4d8ca5128319800c91303a022a4e53ac6aea599;hb=0b3418cf166ce4a58cedf0d9a2df5ec3dd4cc5fa;hp=b6514c05c2b5633a93104524bcd4fa8533c3ba80;hpb=df7cadac556f302bdd0bc48c235c2b61b699dfe1;p=samtools.git diff --git a/bam2bcf.h b/bam2bcf.h index b6514c0..a4d8ca5 100644 --- a/bam2bcf.h +++ b/bam2bcf.h @@ -5,31 +5,41 @@ #include "errmod.h" #include "bcftools/bcf.h" -#define BAM2BCF_INDELREG_THRES 13 +#define B2B_INDEL_NULL 10000 + +#define B2B_FMT_DP 0x1 +#define B2B_FMT_SP 0x2 +#define B2B_FMT_DV 0x4 typedef struct __bcf_callaux_t { - int max_bases, capQ, min_baseQ; - int openQ, extQ, tandemQ; + int capQ, min_baseQ; + int openQ, extQ, tandemQ; // for indels + int min_support; // for collecting indel candidates + double min_frac; // for collecting indel candidates // for internal uses + int max_bases; + int indel_types[4]; + int maxins, indelreg; + char *inscns; uint16_t *bases; errmod_t *e; + void *rghash; } bcf_callaux_t; typedef struct { - int depth, indelreg; - float ins_len, del_len; - int qsum[4]; + int depth, n_supp, ori_depth, qsum[4]; int anno[16]; float p[25]; + int mvd[3]; // mean variant distance, number of variant reads, average read length } bcf_callret1_t; typedef struct { int a[5]; // alleles: ref, alt, alt2, alt3 int n, n_alleles, shift, ori_ref, unseen; - int indelreg; - float ins_len, del_len; - int depth, anno[16]; + int n_supp; // number of supporting non-reference reads + int anno[16], depth, ori_depth; uint8_t *PL; + float vdb; // variant distance bias } bcf_call_t; #ifdef __cplusplus @@ -38,11 +48,12 @@ extern "C" { bcf_callaux_t *bcf_call_init(double theta, int min_baseQ); void bcf_call_destroy(bcf_callaux_t *bca); - int bcf_call_glfgen(int _n, const bam_pileup1_t *pl, int ref_base /*4-bit*/, bcf_callaux_t *bca, bcf_callret1_t *r); + int bcf_call_glfgen(int _n, const bam_pileup1_t *pl, int ref_base, bcf_callaux_t *bca, bcf_callret1_t *r); int bcf_call_combine(int n, const bcf_callret1_t *calls, int ref_base /*4-bit*/, bcf_call_t *call); - int bcf_call_combine_gap(int n, const bcf_callret1_t *calls, bcf_call_t *call); - int bcf_call2bcf(int tid, int pos, bcf_call_t *bc, bcf1_t *b, bcf_callret1_t *bcr, int is_SP); - int bcf_call_glfgen_gap(int pos, int _n, const bam_pileup1_t *pl, bcf_callaux_t *bca, bcf_callret1_t *r); + int bcf_call2bcf(int tid, int pos, bcf_call_t *bc, bcf1_t *b, bcf_callret1_t *bcr, int fmt_flag, + const bcf_callaux_t *bca, const char *ref); + int bcf_call_gap_prep(int n, int *n_plp, bam_pileup1_t **plp, int pos, bcf_callaux_t *bca, const char *ref, + const void *rghash); #ifdef __cplusplus }