-/* dist_dna.c 2010-03-16 */
+/* dist_dna.c 2010-09-16 */
/* Copyright 2005-2010 Emmanuel Paradis
if (KnownBase(x[s1]) && KnownBase(x[s2])) L++;\
else continue;
-void distDNA_raw(unsigned char *x, int *n, int *s, double *d, int scaled)
+#define COUNT_TS_TV\
+ if (SameBase(x[s1], x[s2])) continue;\
+ Nd++;\
+ if (IsPurine(x[s1]) && IsPurine(x[s2])) {\
+ Ns++;\
+ continue;\
+ }\
+ if (IsPyrimidine(x[s1]) && IsPyrimidine(x[s2])) Ns++;
+
+void distDNA_TsTv(unsigned char *x, int *n, int *s, double *d, int Ts, int pairdel)
{
- int i1, i2, s1, s2, target, Nd;
+ int i1, i2, s1, s2, target, Nd, Ns;
+
+ target = 0;
+ for (i1 = 1; i1 < *n; i1++) {
+ for (i2 = i1 + 1; i2 <= *n; i2++) {
+ Nd = Ns = 0;
+ for (s1 = i1 - 1, s2 = i2 - 1; s1 < i1 + *n*(*s - 1); s1+= *n, s2 += *n) {
+ if (pairdel && !(KnownBase(x[s1]) && KnownBase(x[s2]))) continue;
+ COUNT_TS_TV
+ }
+ if (Ts) d[target] = ((double) Ns); /* output number of transitions */
+ else d[target] = ((double) Nd - Ns); /* output number of transversions */
+ target++;
+ }
+ }
+}
- target = 0;
- for (i1 = 1; i1 < *n; i1++) {
- for (i2 = i1 + 1; i2 <= *n; i2++) {
- Nd = 0;
- for (s1 = i1 - 1, s2 = i2 - 1; s1 < i1 + *n*(*s - 1); s1+= *n, s2 += *n)
- if (DifferentBase(x[s1], x[s2])) Nd++;
- if (scaled) d[target] = ((double) Nd / *s);
- else d[target] = ((double) Nd);
- target++;
+void distDNA_raw(unsigned char *x, int *n, int *s, double *d, int scaled)
+{
+ int i1, i2, s1, s2, target, Nd;
+
+ target = 0;
+ for (i1 = 1; i1 < *n; i1++) {
+ for (i2 = i1 + 1; i2 <= *n; i2++) {
+ Nd = 0;
+ for (s1 = i1 - 1, s2 = i2 - 1; s1 < i1 + *n*(*s - 1); s1+= *n, s2 += *n)
+ if (DifferentBase(x[s1], x[s2])) Nd++;
+ if (scaled) d[target] = ((double) Nd / *s);
+ else d[target] = ((double) Nd);
+ target++;
+ }
}
- }
}
void distDNA_raw_pairdel(unsigned char *x, int *n, int *s, double *d, int scaled)
}
}
-#define COUNT_TS_TV\
- if (SameBase(x[s1], x[s2])) continue;\
- Nd++;\
- if (IsPurine(x[s1]) && IsPurine(x[s2])) {\
- Ns++;\
- continue;\
- }\
- if (IsPyrimidine(x[s1]) && IsPyrimidine(x[s2])) Ns++;
-
#define COMPUTE_DIST_K80\
P = ((double) Ns/L);\
Q = ((double) (Nd - Ns)/L);\
#define COMPUTE_DIST_LogDet\
for (k = 0; k < 16; k++) Ftab[k] = ((double) Ntab[k]/L);\
- d[target] = (-log(detFourByFour(Ftab))/4 - LN4)/4;\
+ d[target] = -log(detFourByFour(Ftab))/4 - LN4;\
if (*variance) {\
/* For the inversion, we first make U an identity matrix */\
for (k = 1; k < 15; k++) U[k] = 0;\
for (i2 = i1 + 1; i2 <= *n; i2++) {
for (k = 0; k < 16; k++) Ntab[k] = 0;
for (s1 = i1 - 1, s2 = i2 - 1; s1 < i1 + *n*(*s - 1); s1+= *n, s2 += *n) {
-#define PREPARE_BF_F84\
- A = (BF[0]*BF[2])/(BF[0] + BF[2]) + (BF[1]*BF[3])/(BF[1] + BF[3]);\
- B = BF[0]*BF[2] + BF[1]*BF[3];\
- C = (BF[0] + BF[2])*(BF[1] + BF[3]);
-
-#define COMPUTE_DIST_F84\
- P = ((double) Ns/L);\
- Q = ((double) (Nd - Ns)/L);\
- d[target] = -2*A*log(1 - P/(2*A) - (A - B)*Q/(2*A*C)) + 2*(A - B - C)*log(1 - Q/(2*C));\
- if (*variance) {\
- t1 = A*C;\
- t2 = C*P/2;\
- t3 = (A - B)*Q/2;\
- a = t1/(t1 - t2 - t3);\
- b = A*(A - B)/(t1 - t2 - t3) - (A - B - C)/(C - Q/2);\
- var[target] = (a*a*P + b*b*Q - pow(a*P + b*Q, 2))/2;\
- }
-
-void distDNA_F84(unsigned char *x, int *n, int *s, double *d,
- double *BF, int *variance, double *var)
-{
- int i1, i2, Nd, Ns, L, target, s1, s2;
- double P, Q, A, B, C, a, b, t1, t2, t3;
-
- PREPARE_BF_F84
- L = *s;
-
- target = 0;
- for (i1 = 1; i1 < *n; i1++) {
- for (i2 = i1 + 1; i2 <= *n; i2++) {
- Nd = Ns = 0;
- for (s1 = i1 - 1, s2 = i2 - 1; s1 < i1 + *n*(*s - 1); s1+= *n, s2 += *n) {
- COUNT_TS_TV
- }
- COMPUTE_DIST_F84
- target++;
- }
- }
-}
-
-void distDNA_F84_pairdel(unsigned char *x, int *n, int *s, double *d,
- double *BF, int *variance, double *var)
-{
- int i1, i2, Nd, Ns, L, target, s1, s2;
- double P, Q, A, B, C, a, b, t1, t2, t3;
-
- PREPARE_BF_F84
-
- target = 0;
- for (i1 = 1; i1 < *n; i1++) {
- for (i2 = i1 + 1; i2 <= *n; i2++) {
- Nd = Ns = L = 0;
- for (s1 = i1 - 1, s2 = i2 - 1; s1 < i1 + *n*(*s - 1); s1+= *n, s2 += *n) {
- CHECK_PAIRWISE_DELETION
- COUNT_TS_TV
- }
- COMPUTE_DIST_F84
- target++;
- }
- }
-}
DO_CONTINGENCY_NUCLEOTIDES
}
switch (*model) {
case 1 : if (pairdel) distDNA_raw_pairdel(x, n, s, d, 1);
else distDNA_raw(x, n, s, d, 1); break;
-
case 2 : if (pairdel) distDNA_JC69_pairdel(x, n, s, d, variance, var, gamma, alpha);
else distDNA_JC69(x, n, s, d, variance, var, gamma, alpha); break;
-
case 3 : if (pairdel) distDNA_K80_pairdel(x, n, s, d, variance, var, gamma, alpha);
else distDNA_K80(x, n, s, d, variance, var, gamma, alpha); break;
-
case 4 : if (pairdel) distDNA_F81_pairdel(x, n, s, d, BF, variance, var, gamma, alpha);
else distDNA_F81(x, n, s, d, BF, variance, var, gamma, alpha); break;
-
case 5 : if (pairdel) distDNA_K81_pairdel(x, n, s, d, variance, var);
else distDNA_K81(x, n, s, d, variance, var); break;
-
case 6 : if (pairdel) distDNA_F84_pairdel(x, n, s, d, BF, variance, var);
else distDNA_F84(x, n, s, d, BF, variance, var); break;
-
case 7 : if (pairdel) distDNA_T92_pairdel(x, n, s, d, BF, variance, var);
else distDNA_T92(x, n, s, d, BF, variance, var); break;
-
case 8 : if (pairdel) distDNA_TN93_pairdel(x, n, s, d, BF, variance, var, gamma, alpha);
else distDNA_TN93(x, n, s, d, BF, variance, var, gamma, alpha); break;
-
case 9 : if (pairdel) distDNA_GG95_pairdel(x, n, s, d, variance, var);
else distDNA_GG95(x, n, s, d, variance, var); break;
-
case 10 : if (pairdel) distDNA_LogDet_pairdel(x, n, s, d, variance, var);
else distDNA_LogDet(x, n, s, d, variance, var); break;
-
case 11 : distDNA_BH87(x, n, s, d, variance, var); break;
-
case 12 : if (pairdel) distDNA_ParaLin_pairdel(x, n, s, d, variance, var);
else distDNA_ParaLin(x, n, s, d, variance, var); break;
case 13 : if (pairdel) distDNA_raw_pairdel(x, n, s, d, 0);
else distDNA_raw(x, n, s, d, 0); break;
+ case 14 : if (pairdel) distDNA_TsTv(x, n, s, d, 1, 1);
+ else distDNA_TsTv(x, n, s, d, 1, 0); break;
+ case 15 : if (pairdel) distDNA_TsTv(x, n, s, d, 0, 1);
+ else distDNA_TsTv(x, n, s, d, 0, 0); break;
+
}
}