#include <string.h>
#include <stdlib.h>
+#include <sys/stat.h>
#include "bcf.h"
int bcfview(int argc, char *argv[]);
int bcf_main_index(int argc, char *argv[]);
-int vcf_test(int argc, char *argv[]);
+
+#define BUF_SIZE 0x10000
+
+int bcf_cat(int n, char * const *fn)
+{
+ int i;
+ bcf_t *out;
+ uint8_t *buf;
+ buf = malloc(BUF_SIZE);
+ out = bcf_open("-", "w");
+ for (i = 0; i < n; ++i) {
+ bcf_t *in;
+ bcf_hdr_t *h;
+ off_t end;
+ struct stat s;
+ in = bcf_open(fn[i], "r");
+ h = bcf_hdr_read(in);
+ if (i == 0) bcf_hdr_write(out, h);
+ bcf_hdr_destroy(h);
+#ifdef _USE_KNETFILE
+ fstat(knet_fileno(in->fp->x.fpr), &s);
+ end = s.st_size - 28;
+ while (knet_tell(in->fp->x.fpr) < end) {
+ int size = knet_tell(in->fp->x.fpr) + BUF_SIZE < end? BUF_SIZE : end - knet_tell(in->fp->x.fpr);
+ knet_read(in->fp->x.fpr, buf, size);
+ fwrite(buf, 1, size, out->fp->x.fpw);
+ }
+#else
+ abort(); // FIXME: not implemented
+#endif
+ bcf_close(in);
+ }
+ bcf_close(out);
+ free(buf);
+ return 0;
+}
+
+int bcf_main_pwld(int argc, char *argv[])
+{
+ extern double bcf_pair_freq(const bcf1_t *b0, const bcf1_t *b1, double f[4]);
+ bcf_t *fp;
+ bcf_hdr_t *h;
+ bcf1_t **b, *b0;
+ int i, j, m, n;
+ double f[4];
+ if (argc == 1) {
+ fprintf(stderr, "Usage: bcftools pwld <in.bcf>\n");
+ return 1;
+ }
+ fp = bcf_open(argv[1], "rb");
+ h = bcf_hdr_read(fp);
+ // read the entire BCF
+ m = n = 0; b = 0;
+ b0 = calloc(1, sizeof(bcf1_t));
+ while (bcf_read(fp, h, b0) >= 0) {
+ if (m == n) {
+ m = m? m<<1 : 16;
+ b = realloc(b, sizeof(void*) * m);
+ }
+ b[n] = calloc(1, sizeof(bcf1_t));
+ bcf_cpy(b[n++], b0);
+ }
+ bcf_destroy(b0);
+ // compute pair-wise r^2
+ printf("%d\n", n); // the number of loci
+ for (i = 0; i < n; ++i) {
+ printf("%s:%d", h->ns[b[i]->tid], b[i]->pos + 1);
+ for (j = 0; j < i; ++j) {
+ double r = bcf_pair_freq(b[i], b[j], f);
+ printf("\t%.3f", r*r);
+ }
+ printf("\t1.000\n");
+ }
+ // free
+ for (i = 0; i < n; ++i) bcf_destroy(b[i]);
+ free(b);
+ bcf_hdr_destroy(h);
+ bcf_close(fp);
+ return 0;
+}
int main(int argc, char *argv[])
{
fprintf(stderr, "Usage: bcftools <command> <arguments>\n\n");
fprintf(stderr, "Command: view print, extract, convert and call SNPs from BCF\n");
fprintf(stderr, " index index BCF\n");
+ fprintf(stderr, " cat concatenate BCFs\n");
+ fprintf(stderr, " ld compute all-pair r^2\n");
fprintf(stderr, "\n");
return 1;
}
if (strcmp(argv[1], "view") == 0) return bcfview(argc-1, argv+1);
- if (strcmp(argv[1], "index") == 0) return bcf_main_index(argc-1, argv+1);
- if (strcmp(argv[1], "test") == 0) return vcf_test(argc-1, argv+1);
+ else if (strcmp(argv[1], "index") == 0) return bcf_main_index(argc-1, argv+1);
+ else if (strcmp(argv[1], "ld") == 0) return bcf_main_pwld(argc-1, argv+1);
+ else if (strcmp(argv[1], "cat") == 0) return bcf_cat(argc-2, argv+2); // cat is different ...
else {
fprintf(stderr, "[main] Unrecognized command.\n");
return 1;