8 KSTREAM_INIT(gzFile, gzread, 4096)
19 bcf_hdr_t *vcf_hdr_read(bcf_t *bp)
25 if (!bp->is_vcf) return bcf_hdr_read(bp);
26 h = calloc(1, sizeof(bcf_hdr_t));
29 memset(&meta, 0, sizeof(kstring_t));
30 memset(&smpl, 0, sizeof(kstring_t));
31 while (ks_getuntil(v->ks, '\n', &v->line, &dret) >= 0) {
32 if (v->line.l < 2) continue;
33 if (v->line.s[0] != '#') return 0; // no sample line
34 if (v->line.s[0] == '#' && v->line.s[1] == '#') {
35 kputsn(v->line.s, v->line.l, &meta); kputc('\n', &meta);
36 } else if (v->line.s[0] == '#') {
40 for (p = kstrtok(v->line.s, "\t\n", &aux), k = 0; p; p = kstrtok(0, 0, &aux), ++k) {
42 kputsn(p, aux.p - p, &smpl);
51 h->sname = smpl.s; h->l_smpl = smpl.l;
52 h->txt = meta.s; h->l_txt = meta.l;
57 bcf_t *vcf_open(const char *fn, const char *mode)
61 if (strchr(mode, 'b')) return bcf_open(fn, mode);
62 bp = calloc(1, sizeof(bcf_t));
63 v = calloc(1, sizeof(vcf_t));
66 v->refhash = bcf_str2id_init();
67 if (strchr(mode, 'r')) {
68 v->fp = strcmp(fn, "-")? gzopen(fn, "r") : gzdopen(fileno(stdin), "r");
69 v->ks = ks_init(v->fp);
70 } else if (strchr(mode, 'w'))
71 v->fpout = strcmp(fn, "-")? fopen(fn, "w") : stdout;
75 int vcf_dictread(bcf_t *bp, bcf_hdr_t *h, const char *fn)
82 if (bp == 0) return -1;
83 if (!bp->is_vcf) return 0;
84 s.l = s.m = 0; s.s = 0;
85 rn.m = rn.l = h->l_nm; rn.s = h->name;
89 while (ks_getuntil(ks, 0, &s, &dret) >= 0) {
90 bcf_str2id_add(v->refhash, strdup(s.s));
91 kputs(s.s, &rn); kputc('\0', &rn);
92 if (dret != '\n') ks_getuntil(ks, '\n', &s, &dret);
96 h->l_nm = rn.l; h->name = rn.s;
102 int vcf_close(bcf_t *bp)
105 if (bp == 0) return -1;
106 if (!bp->is_vcf) return bcf_close(bp);
112 if (v->fpout) fclose(v->fpout);
114 bcf_str2id_thorough_destroy(v->refhash);
120 int vcf_hdr_write(bcf_t *bp, const bcf_hdr_t *h)
122 vcf_t *v = (vcf_t*)bp->v;
124 if (!bp->is_vcf) return bcf_hdr_write(bp, h);
126 if (strstr(h->txt, "##fileformat=")) has_ver = 1;
127 if (has_ver == 0) fprintf(v->fpout, "##fileformat=VCFv4.1\n");
128 fwrite(h->txt, 1, h->l_txt - 1, v->fpout);
130 if (h->l_txt == 0) fprintf(v->fpout, "##fileformat=VCFv4.1\n");
131 fprintf(v->fpout, "#CHROM\tPOS\tID\tREF\tALT\tQUAL\tFILTER\tINFO\tFORMAT");
132 for (i = 0; i < h->n_smpl; ++i)
133 fprintf(v->fpout, "\t%s", h->sns[i]);
134 fputc('\n', v->fpout);
138 int vcf_write(bcf_t *bp, bcf_hdr_t *h, bcf1_t *b)
140 vcf_t *v = (vcf_t*)bp->v;
141 extern void bcf_fmt_core(const bcf_hdr_t *h, bcf1_t *b, kstring_t *s);
142 if (!bp->is_vcf) return bcf_write(bp, h, b);
143 bcf_fmt_core(h, b, &v->line);
144 fwrite(v->line.s, 1, v->line.l, v->fpout);
145 fputc('\n', v->fpout);
146 return v->line.l + 1;
149 int vcf_read(bcf_t *bp, bcf_hdr_t *h, bcf1_t *b)
151 int dret, k, i, sync = 0;
152 vcf_t *v = (vcf_t*)bp->v;
156 if (!bp->is_vcf) return bcf_read(bp, h, b);
158 str.l = 0; str.m = b->m_str; str.s = b->str;
159 rn.l = rn.m = h->l_nm; rn.s = h->name;
160 if (ks_getuntil(v->ks, '\n', &v->line, &dret) < 0) return -1;
161 b->n_smpl = h->n_smpl;
162 for (p = kstrtok(v->line.s, "\t", &aux), k = 0; p; p = kstrtok(0, 0, &aux), ++k) {
165 int tid = bcf_str2id(v->refhash, p);
167 tid = bcf_str2id_add(v->refhash, strdup(p));
168 kputs(p, &rn); kputc('\0', &rn);
172 } else if (k == 1) { // pos
173 b->pos = atoi(p) - 1;
174 } else if (k == 5) { // qual
175 b->qual = (p[0] >= '0' && p[0] <= '9')? atof(p) : 0;
176 } else if (k <= 8) { // variable length strings
177 kputs(p, &str); kputc('\0', &str);
178 b->l_str = str.l; b->m_str = str.m; b->str = str.s;
179 if (k == 8) bcf_sync(b);
181 if (strncmp(p, "./.", 3) == 0) {
182 for (i = 0; i < b->n_gi; ++i) {
183 if (b->gi[i].fmt == bcf_str2int("GT", 2)) {
184 ((uint8_t*)b->gi[i].data)[k-9] = 1<<7;
185 } else if (b->gi[i].fmt == bcf_str2int("GQ", 2)) {
186 ((uint8_t*)b->gi[i].data)[k-9] = 0;
187 } else if (b->gi[i].fmt == bcf_str2int("SP", 2)) {
188 ((int32_t*)b->gi[i].data)[k-9] = 0;
189 } else if (b->gi[i].fmt == bcf_str2int("DP", 2) || b->gi[i].fmt == bcf_str2int("DV", 2)) {
190 ((uint16_t*)b->gi[i].data)[k-9] = 0;
191 } else if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
192 int y = b->n_alleles * (b->n_alleles + 1) / 2;
193 memset((uint8_t*)b->gi[i].data + (k - 9) * y, 0, y);
194 } else if (b->gi[i].fmt == bcf_str2int("GL", 2)) {
195 int y = b->n_alleles * (b->n_alleles + 1) / 2;
196 memset((float*)b->gi[i].data + (k - 9) * y, 0, y * 4);
201 for (q = kstrtok(p, ":", &a2), i = 0; q && i < b->n_gi; q = kstrtok(0, 0, &a2), ++i) {
202 if (b->gi[i].fmt == bcf_str2int("GT", 2)) {
203 ((uint8_t*)b->gi[i].data)[k-9] = (q[0] - '0')<<3 | (q[2] - '0') | (q[1] == '/'? 0 : 1) << 6;
204 } else if (b->gi[i].fmt == bcf_str2int("GQ", 2)) {
205 double _x = strtod(q, &q);
206 int x = (int)(_x + .499);
207 if (x > 255) x = 255;
208 ((uint8_t*)b->gi[i].data)[k-9] = x;
209 } else if (b->gi[i].fmt == bcf_str2int("SP", 2)) {
210 int x = strtol(q, &q, 10);
211 if (x > 0xffff) x = 0xffff;
212 ((uint32_t*)b->gi[i].data)[k-9] = x;
213 } else if (b->gi[i].fmt == bcf_str2int("DP", 2) || b->gi[i].fmt == bcf_str2int("DV", 2)) {
214 int x = strtol(q, &q, 10);
215 if (x > 0xffff) x = 0xffff;
216 ((uint16_t*)b->gi[i].data)[k-9] = x;
217 } else if (b->gi[i].fmt == bcf_str2int("PL", 2)) {
219 uint8_t *data = (uint8_t*)b->gi[i].data;
220 y = b->n_alleles * (b->n_alleles + 1) / 2;
221 for (j = 0; j < y; ++j) {
222 x = strtol(q, &q, 10);
223 if (x > 255) x = 255;
224 data[(k-9) * y + j] = x;
227 } else if (b->gi[i].fmt == bcf_str2int("GL", 2)) {
229 float x, *data = (float*)b->gi[i].data;
230 y = b->n_alleles * (b->n_alleles + 1) / 2;
231 for (j = 0; j < y; ++j) {
233 data[(k-9) * y + j] = x > 0? -x/10. : x;
241 h->l_nm = rn.l; h->name = rn.s;
242 if (sync) bcf_hdr_sync(h);
243 return v->line.l + 1;